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1994-10-25
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Document 2661
DOCN M94A2661
TI Poor pregnant women and HIV-1 infection: maternal prognosis in a
Brazilian community.
DT 9412
AU Duarte G; Quintana SM; Gir E; Marana HR; Mussi-Pinhata MM; Clinical
Hospital of Medicine Scholl of Ribeirao Preto-University; of Sao
Paulo-Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):253 (abstract no. PB0440). Unique
Identifier : AIDSLINE ICA10/94369914
AB OBJECTIVES: 1) To determine the yearly prevalences of anti-HIV-1
seropositivity among poor parturients in Ribeirao Preto, Brazil.; 2) To
evaluate clinically the effects of pregnancy on the HIV-1 infection
prognosis, considering its clinical stages. METHODS: A prospective
survey was carried out from 1987 to 1993 among 221 HIV-1 infected
parturients cared at a University Hospital. The influence of pregnancy
on the HIV-1 infection prognosis was analysed in 107 parturients based
specially on clinical parameters (CD4 count not available). The data
were compared with control groups composed by HIV-1 infected
non-obstetric female population. Kaplan-Meyer Method and Exact Fisher
Test were used for statistical analysis. RESULTS: The yearly prevalence
rates by 1,000 births were: 1.9 in 1987; 5.4 in 1988; 10.8 in 1989; 13.1
in 1990; 20.6 in 1991; 21.1 in 1992; 21.2 in 1993. A total of 16
parturients in stages III/IV of HIV-1 infection were followed-up for 17
months. The mortality rate was higher in this group (55.5%) than in the
control group (31.2%), specially during the first trimester after the
delivery. The 91 parturients in stage II were followed-up for 30 months
In this group the infection had a faster evolution from stage II to IV
(69.2%), in comparison to the control group (42.9%), mainly after the
first year of delivery. DISCUSSION AND CONCLUSIONS: The poor maternal
prognosis observed among these parturients can be the result of HIV-1
infection in addition to malnutrition, lack of prenatal caring and other
infections associated. Such conditions are constant in developing
countries and different from the developed ones. The increasing number
of anti-HIV-1 seropositive parturients and the compromised maternal
prognosis observed in these patients do reinforce the need to promote
counselling that do not stimulate reproduction in this group of women,
unless an effective therapeutic for HIV infection be discovered.
DE Brazil/EPIDEMIOLOGY *Developing Countries Female Follow-Up Studies
Human HIV Infections/CLASSIFICATION/*MORTALITY/TRANSMISSION HIV
Seroprevalence *HIV-1 Infant, Newborn Poverty/*STATISTICS & NUMER
DATA Pregnancy Pregnancy Complications,
Infectious/CLASSIFICATION/ETIOLOGY/ *MORTALITY Prospective Studies
Risk Factors Survival Analysis MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).